Entry 2 senses · 2 variants Webster, 1913 Abirritant · Ab·ir·ri·tant · IPA /æbˈɪɹ.ɪ.tn̩t/ n. adj. 01 n. A medicine that diminishes or alleviates irritation. 1. A medicine that diminishes or alleviates irritation.(Med.) 02 adj. Diminishing or alleviating irritation 1. Diminishing or alleviating irritation(Med.)