Entry 1 sense Webster, 1913 adenopathy /(ăd`ē̇*nŏp"ȧ*thy̆)/ · ad·e·nop·a·thy · IPA /æ.dəˈnɑ.pə.θi/ 01 n. Pathological enlargement of a lymph node. 1. Pathological enlargement of a lymph node.(Med.)