Entry 1 sense Webster, 1913 Afresh /əf-rĕsh'/ · A·fresh · IPA /ʌˈfɹɛʃ/ 01 adv. Anew; again; once more; newly. 1. Anew; again; once more; newly. “They crucify . . . the Son of God afresh.” — Heb. vi. 6.