Entry 1 sense Webster, 1913 amblyopia /(ăm`blē̇*ō"pē̇*ȧ)/ · am·bly·o·pi·a · IPA /æmblɪˈəʊpɪə/ 01 n. Weakness of sight, without any detectable organic lesion. 1. Weakness of sight, without any detectable organic lesion.(Med.)