Entry 1 sense Webster, 1913 Appendectomy /ăpˌ-ĭn-dĕk'-təm-ē/ · Ap·pen·dec·to·my · IPA /ˌæpɪndˈɛktəmiː/ 01 n. Excision of the vermiform appendix. 1. Excision of the vermiform appendix.(Surg.)