Entry 2 senses · 2 variants Webster, 1913 Disprofit · Dis·prof·it · IPA n. v. i. & i. 01 n. Loss; damage. 1. Loss; damage. 02 v. i. & i. To be, or to cause to be, without profit or benefit. 1. To be, or to cause to be, without profit or benefit.[Obs. or Archaic]