Entry 1 sense Webster, 1913 echinocyte /(ĕk"ĭ*nō̇*sīt)/ · ech·i·no·cyte · IPA /ɪˈkaɪnəsaɪt/ 01 n. a red blood cell which has become crenated. 1. a red blood cell which has become crenated.(Biol.)