Entry 1 sense Webster, 1913 Exinanition · Ex·in·a·ni·tion · IPA /ˌɛɡzɪnəˈnɪʃən/ 01 n. An emptying; an enfeebling; exhaustion; humiliation. 1. An emptying; an enfeebling; exhaustion; humiliation.[Obs.] “Fastings to the exinanition of spirits.” — Jer. Taylor.