Entry 1 sense Webster, 1913 Frustration /frəs-trāsh'-ən/ · Frus·tra·tion · IPA /fɹʌsˈtɹeɪ.ʃən/ 01 n. The act of frustrating; disappointment; defeat; as, the frustration of one's designs. 1. The act of frustrating; disappointment; defeat; as, the frustration of one's designs.