Entry 1 sense Webster, 1913 HS2 · IPA 01 n. Herpes simplex 2, a herpes virus that can cause genital herpes; also called type II Herpes. 1. Herpes simplex 2, a herpes virus that can cause genital herpes; also called type II Herpes. Also: type II Herpes Syn. herpes simplex 2.