Entry 1 sense Webster, 1913 Hybridization /hībˌ-rəd-əz-āsh'-ən/ · Hy·brid·i·za·tion · IPA /haɪ.bɹɪd.aɪˈzeɪ.ʃən/ 01 n. The act of hybridizing, or the state of being hybridized. 1. The act of hybridizing, or the state of being hybridized.