Entry 1 sense Webster, 1913 Insalubrious · In·sa·lu·bri·ous · IPA /ɪnsəˈluːbɹɪəs/ 01 a. Not salubrious or healthful; unwholesome; as, an insalubrious air or climate. 1. Not salubrious or healthful; unwholesome; as, an insalubrious air or climate.