Entry 1 sense Webster, 1913 Lady's thumb /(lā"dĭz thŭm")/ · La·dy's thumb · IPA 01 n. An annual weed (Polygonum Persicaria), having a lanceolate leaf with a dark spot in the middle. 1. An annual weed (Polygonum Persicaria), having a lanceolate leaf with a dark spot in the middle.(Bot.)