Entry 2 senses Webster, 1913 Leprous /(-rūs)/ · Lep·rous · IPA /ˈlɛpɹəs/ 01 a. Infected with leprosy; pertaining to or resembling leprosy. 1. Infected with leprosy; pertaining to or resembling leprosy. 2. Leprose.(Nat. Hist.)