Entry 1 sense Webster, 1913 Metabolize /mət-ăb'-əl-īzˌ/ · Me·tab·o·lize · IPA /mɪˈtæbəˌlaɪz/ 01 v. t. & i. To change by a metabolic process. See Metabolism. 1. To change by a metabolic process. See Metabolism.(Physiol.) See: Metabolism