Entry 2 senses · 2 variants Webster, 1913 Palliative /păl'-ē-ət-ĭv/ · Pal·li·a·tive · IPA /ˈpælieɪtɪv/ a. n. 01 a. Serving to palliate; serving to extenuate, mitigate, or alleviate. 1. Serving to palliate; serving to extenuate, mitigate, or alleviate. 02 n. That which palliates; a palliative agent. 1. That which palliates; a palliative agent.