Entry 1 sense Webster, 1913 Pepo /(pē"pō̇)/ · Pe·po · IPA /ˈpi.poʊ/ 01 n. Any fleshy fruit with a firm rind, as a pumpkin, melon, or gourd. See Gourd. 1. Any fleshy fruit with a firm rind, as a pumpkin, melon, or gourd. See Gourd.(Bot.) See: Gourd