Entry 2 senses · 2 variants Webster, 1913 Pernicious /pẽrn-ĭsh'-əs/ · Per·ni·cious · IPA /pɚˈnɪʃəs/ a. a. 01 a. Quick; swift (to burn). 1. Quick; swift (to burn).[R.] 02 a. Having the quality of injuring or killing; destructive; very mischievous; baleful; malicious; wicked. 1. Having the quality of injuring or killing; destructive; very mischievous; baleful; malicious; wicked. “Let this pernicious hour Stand aye accursed in the calendar.” — Shak. “Pernicious to his health.” — Prescott. Syn. Destructive; ruinous; deadly; noxious; injurious; baneful; deleterious; hurtful; mischievous.