Entry 2 senses · 2 variants Webster, 1913 piss off · IPA v. t. v. i. 01 v. t. To anger or strongly annoy; as, his flippant attitude pissed off the teacher. 1. To anger or strongly annoy; as, his flippant attitude pissed off the teacher.[vulgar] 02 v. i. To leave immediately; to scram; -- chiefly British, and sometimes considered vulgar. 1. To leave immediately; to scram; -- chiefly British, and sometimes considered vulgar.[Brit., vulgar]