Entry 2 senses · 2 variants Webster, 1913 Polychrome /päl'-ēkˌ-rōmˌ/ · Pol·y·chrome · IPA /pˈɑlˌiːkrˌoʊm/ n. a. 01 n. Esculin; -- so called in allusion to its fluorescent solutions. 1. Esculin; -- so called in allusion to its fluorescent solutions.(Chem.) [R.] 02 a. Executed in the manner of polychromy; as, polychrome printing. 1. Executed in the manner of polychromy; as, polychrome printing.