Entry 2 senses Webster, 1913 Predestination /prēdˌ-ĕsˌ-tən-āsh'-ən/ · Pre·des·ti·na·tion · IPA /pɹi.dɛs.tɪˈneɪ.ʃən/ 01 n. The act of predestinating. 1. The act of predestinating. “Predestination had overruled their will.” — Milton. 2. The purpose of Good from eternity respecting all events; especially, the preordination of men to everlasting happiness or misery. See Calvinism.(Theol.) See: Calvinism