Entry 1 sense Webster, 1913 Sophistication /səf-ĭsˌ-tək-āsh'-ən/ · So·phis·ti·ca·tion · IPA /səˌfɪs.tɪˈkeɪ.ʃən/ 01 n. The act of sophisticating; adulteration; as, the sophistication of drugs. 1. The act of sophisticating; adulteration; as, the sophistication of drugs.