Entry 3 senses · 2 variants Webster, 1913 Uptake /ŭp'-tākˌ/ · Up·take · IPA /ˈʌpteɪk/ v. t. n. 01 v. t. To take into the hand; to take up; to help. 1. To take into the hand; to take up; to help.[Obs.] 02 n. The pipe leading upward from the smoke box of a steam boiler to the chimney, or smokestack; a flue leading upward. 1. The pipe leading upward from the smoke box of a steam boiler to the chimney, or smokestack; a flue leading upward. 2. Understanding; apprehension.[Scot.]