01 n. Regular change or succession from one thing to another; alternation; mutual succession; interchange.
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1.
Regular change or succession from one thing to another; alternation; mutual succession; interchange.“God made two great lights . . . To illuminate the earth and rule the day In their vicissitude, and rule the night.” — Milton.
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2.
Irregular change; revolution; mutation.
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3.
Changing conditions of fortune in one's life; life's ups and downs.“This man had, after many vicissitudes of fortune, sunk at last into abject and hopeless poverty.” — Macaulay.