Entry 2 senses · 2 variants Webster, 1913 Wesleyan /wĕz'-lē-ən/ · Wes·ley·an · IPA /ˈwɛz.li.ən/ a. n. 01 a. Of or pertaining to Wesley or Wesleyanism. 1. Of or pertaining to Wesley or Wesleyanism. 02 n. One who adopts the principles of Wesleyanism; a Methodist. 1. One who adopts the principles of Wesleyanism; a Methodist.(Eccl.)