Entry 1 sense Webster, 1913 pachydermatosis /(păk*ĭ*dẽr`mȧ*tō"sĭs)/ · pach·y·der·ma·to·sis · IPA 01 n. Same as pachyderma. 1. Same as pachyderma.(Med.) See: pachyderma Syn. pachyderma, pachydermia, nevoid elephantiasis.