Entry 1 sense Webster, 1913 pachydermia /(păk`ĭ*dẽr"mĭ*ȧĭs)/ · pach·y·der·mi·a · IPA 01 n. Same as pachyderma. 1. Same as pachyderma.(Med.) See: pachyderma Syn. pachydermatosis, pachyderma, nevoid elephantiasis.